Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction.

ABSTRACT: There exists much variability in susceptibility/resilience to addiction in humans. The environmental enrichment paradigm is a rat model of resilience to addiction-like behavior, and understanding the molecular mechanisms underlying this protective phenotype may lead to novel targets for pharmacotherapeutics to treat cocaine addiction. We investigated the differential regulation of transcript levels using RNA sequencing of the rat nucleus accumbens after environmental enrichment/isolation and cocaine/saline self-administration. Ingenuity Pathways Analysis and Gene Set Enrichment Analysis of 14,309 transcripts demonstrated that many biofunctions and pathways were differentially regulated. New functional pathways were also identified for cocaine modulation (e.g., Rho GTPase signaling) and env

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5110542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature