Run-and-pause dynamics of cytoskeletal motor proteins.

ABSTRACT: Cytoskeletal motor proteins are involved in major intracellular transport processes which are vital for maintaining appropriate cellular function. When attached to cytoskeletal filaments, the motor exhibits distinct states of motility: active motion along the filaments, and pause phase in which it remains stationary for a finite time interval. The transition probabilities between motion and pause phases are asymmetric in general, and considerably affected by changes in environmental conditions which influences the efficiency of cargo delivery to specific targets. By considering the motion of individual non-interacting molecular motors on a single filament as well as a dynamic filamentous network, we present an analytical model for the dynamics of self-propelled particles which undergo freq

SUBMITTER: Hafner AE 

PROVIDER: S-EPMC5111058 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature