Listeria monocytogenes sequence type 1 is predominant in ruminant rhombencephalitis.

ABSTRACT: Listeria (L.) monocytogenes is an opportunistic pathogen causing life-threatening infections in diverse mammalian species including humans and ruminants. As little is known on the link between strains and clinicopathological phenotypes, we studied potential strain-associated virulence and organ tropism in L. monocytogenes isolates from well-defined ruminant cases of clinical infections and the farm environment. The phylogeny of isolates and their virulence-associated genes were analyzed by multilocus sequence typing (MLST) and sequence analysis of virulence-associated genes. Additionally, a panel of representative isolates was subjected to in vitro infection assays. Our data suggest the environmental exposure of ruminants to a broad range of strains and yet the strong association of sequen

SUBMITTER: Dreyer M 

PROVIDER: S-EPMC5111077 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature