Safety and feasibility of cell-based therapy of autologous bone marrow-derived mononuclear cells in plate-stabilized proximal humeral fractures in humans.

ABSTRACT:

Background

Local implantation of ex vivo concentrated, washed and filtrated human bone marrow-derived mononuclear cells (BMC) seeded onto β-tricalciumphosphate (TCP) significantly enhanced bone healing in a preclinical segmental defect model. Based on these results, we evaluated in a first clinical phase-I trial safety and feasibility of augmentation with preoperatively isolated autologous BMC seeded onto β-TCP in combination with angle stable plate fixation for the therapy of proximal humeral fractures as a potential alternative to autologous bone graft from the iliac crest.

Methods

10 patients were enrolled to assess whether cell therapy with 1.3 × 10⁶ autologous BMC/ml/ml β-TCP, collected on the day preceding the definitive surgery, is safe and feasible when se

SUBMITTER: Seebach C 

PROVIDER: S-EPMC5111224 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature