Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand.

ABSTRACT:

Background

Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be important in the development of treatment strategies to eradicate HIV-1 or achieve a functional cure.

Methods

We performed twice-weekly qualitative plasma HIV-1 RNA nucleic acid testing in 2276 volunteers who were at high risk for HIV-1 infection. For participants in whom acute HIV-1 infection was detected, clinical observations, quantitative measurements of plasma HIV-1 RNA levels (to assess viremia) and HIV antibodies, and results of immunophenotyping of lymphocytes were obtained twice weekly.

Results

Fifty of 112 volunteers with acute HIV-1 infection had two or more blood samples collected before HI

SUBMITTER: Robb ML 

PROVIDER: S-EPMC5111628 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature