Temperature-Robust Neural Function from Activity-Dependent Ion Channel Regulation.

ABSTRACT: Many species of cold-blooded animals experience substantial and rapid fluctuations in body temperature. Because biological processes are differentially temperature dependent, it is difficult to understand how physiological processes in such animals can be temperature robust [1-8]. Experiments have shown that core neural circuits, such as the pyloric circuit of the crab stomatogastric ganglion (STG), exhibit robust neural activity in spite of large (20°C) temperature fluctuations [3, 5, 7, 8]. This robustness is surprising because (1) each neuron has many different kinds of ion channels with different temperature dependencies (Q₁₀s) that interact in a highly nonlinear way to produce firing patterns and (2) across animals there is substantial variability in conductance densities t

SUBMITTER: O'Leary T 

PROVIDER: S-EPMC5111818 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature