The role of adipokines in the rapid antidepressant effects of ketamine.

ABSTRACT: We previously found that body mass index (BMI) strongly predicted response to ketamine. Adipokines have a key role in metabolism (including BMI). They directly regulate inflammation and neuroplasticity pathways and also influence insulin sensitivity, bone metabolism and sympathetic outflow; all of these have been implicated in mood disorders. Here, we sought to examine the role of three key adipokines-adiponectin, resistin and leptin-as potential predictors of response to ketamine or as possible transducers of its therapeutic effects. Eighty treatment-resistant subjects who met DSM-IV criteria for either major depressive disorder (MDD) or bipolar disorder I/II and who were currently experiencing a major depressive episode received a single ketamine infusion (0.5 mg kg^-1 for 40 m

SUBMITTER: Machado-Vieira R 

PROVIDER: S-EPMC5112162 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature