Sponge Microbiota Are a Reservoir of Functional Antibiotic Resistance Genes.

ABSTRACT: Wide application of antibiotics has contributed to the evolution of multi-drug resistant human pathogens, resulting in poorer treatment outcomes for infections. In the marine environment, seawater samples have been investigated as a resistance reservoir; however, no studies have methodically examined sponges as a reservoir of antibiotic resistance. Sponges could be important in this respect because they often contain diverse microbial communities that have the capacity to produce bioactive metabolites. Here, we applied functional metagenomics to study the presence and diversity of functional resistance genes in the sponges Aplysina aerophoba, Petrosia ficiformis, and Corticium candelabrum. We obtained 37 insert sequences facilitating resistance to D-cycloserine (n = 6)

SUBMITTER: Versluis D 

PROVIDER: S-EPMC5112248 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature