Characterization of 5-(2- ¹⁸F-fluoroethoxy)-L-tryptophan for PET imaging of the pancreas.

ABSTRACT: Purpose: In diabetes, pancreatic beta cell mass declines significantly prior to onset of fasting hyperglycemia. This decline may be due to endoplasmic reticulum (ER) stress, and the system L amino acid transporter LAT1 may be a biomarker of this process. In this study, we used 5-(2- ¹⁸F-fluoroethoxy)-L-tryptophan ( ¹⁸F-L-FEHTP) to target LAT1 as a potential biomarker of beta cell function in diabetes. Procedures: Uptake of ¹⁸F-L-FEHTP was determined in wild-type C57BL/6 mice by ex vivo biodistribution. Both dynamic and static positron emission tomography (PET) images were acquired in wild-type and Akita mice, a model of ER stress-induced diabetes, as well as in mice treated with streptozotocin (STZ). LAT1 expression in both groups of mi

SUBMITTER: Abbas A 

PROVIDER: S-EPMC5112576 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature