Genomic differentiation among wild cyanophages despite widespread horizontal gene transfer.

ABSTRACT:

Background

Genetic recombination is a driving force in genome evolution. Among viruses it has a dual role. For genomes with higher fitness, it maintains genome integrity in the face of high mutation rates. Conversely, for genomes with lower fitness, it provides immediate access to sequence space that cannot be reached by mutation alone. Understanding how recombination impacts the cohesion and dissolution of individual whole genomes within viral sequence space is poorly understood across double-stranded DNA bacteriophages (a.k.a phages) due to the challenges of obtaining appropriately scaled genomic datasets.

Results

Here we explore the role of recombination in both maintaining and differentiating whole genomes of 142 wild double-stranded DNA marine cyanophages. Phylogenomic

SUBMITTER: Gregory AC 

PROVIDER: S-EPMC5112629 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature