E-cadherin genetic variants predict survival outcome in breast cancer patients.

ABSTRACT:

Background

E-cadherin is a major component of adherens junctions that regulates cell shape and maintains tissue integrity. A complete loss or any decrease in cell surface expression of E-cadherin will interfere with the cell-to-cell junctions' strength and leads to cell detachment and escape from the primary tumor site. In this prospective study, three functional single nucleotide polymorphisms (-347G/GA, rs5030625; -160C/A, rs16260; +54C/T, rs1801026), were found to modulate E-cadherin expression.

Methods

577 DNA samples from breast cancer (BC) cases were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results

We detected no significant correlations between each polymorphism and the clinical parameters of the patients where

SUBMITTER: Memni H 

PROVIDER: S-EPMC5112645 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature