Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia.

ABSTRACT:

Background

Multiplex polymerase chain reaction (mPCR) enables recovery of viruses from airways of patients with community-acquired pneumonia (CAP), although their clinical impact remains uncertain.

Methods

Among consecutive adult patients who had undergone a mPCR within 72 hours following their admission to one intensive care unit (ICU), we retrospectively included those with a final diagnosis of CAP. Four etiology groups were clustered: bacterial, viral, mixed (viral-bacterial) and no etiology. A composite criterion of complicated course (hospital death or mechanical ventilation > 7 days) was used. A subgroup analysis compared patients with bacterial and viral-bacterial CAP matched on the bacterial pathogens.

Results

Among 174 patients (132 men [76 %], age 63 [53-75]

SUBMITTER: Voiriot G 

PROVIDER: S-EPMC5112669 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature