Introducing a Clustering Step in a Consensus Approach for the Scoring of Protein-Protein Docking Models.

ABSTRACT: Correctly scoring protein-protein docking models to single out native-like ones is an open challenge. It is also an object of assessment in CAPRI (Critical Assessment of PRedicted Interactions), the community-wide blind docking experiment. We introduced in the field the first pure consensus method, CONSRANK, which ranks models based on their ability to match the most conserved contacts in the ensemble they belong to. In CAPRI, scorers are asked to evaluate a set of available models and select the top ten ones, based on their own scoring approach. Scorers' performance is ranked based on the number of targets/interfaces for which they could provide at least one correct solution. In such terms, blind testing in CAPRI Round 30 (a joint prediction round with CASP11) has shown that critical case

SUBMITTER: Chermak E 

PROVIDER: S-EPMC5112798 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature