Genetic Correlation between Body Fat Percentage and Cardiorespiratory Fitness Suggests Common Genetic Etiology.

ABSTRACT:

Objectives

It has long been discussed whether fitness or fatness is a more important determinant of health status. If the same genetic factors that promote body fat percentage (body fat%) are related to cardiorespiratory fitness (CRF), part of the concurrent associations with health outcomes could reflect a common genetic origin. In this study we aimed to 1) examine genetic correlations between body fat% and CRF; 2) determine whether CRF can be attributed to a genetic risk score (GRS) based on known body fat% increasing loci; and 3) examine whether the fat mass and obesity associated (FTO) locus associates with CRF.

Methods

Genetic correlations based on pedigree information were examined in a family based cohort (n = 230 from 55 families). For the genetic association analyse

SUBMITTER: Schnurr TM 

PROVIDER: S-EPMC5112859 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature