Utilization of bench-stable and readily available nickel(II) triflate for access to 1,2-cis-2-aminoglycosides.

ABSTRACT: The utilization of substoichiometric amounts of commercially available nickel(II) triflate as an activator in the reagent-controlled glycosylation reaction for the stereoselective construction of biologically relevant targets containing 1,2-cis-2-amino glycosidic linkages is reported. This straightforward and accessible methodology is mild, operationally simple and safe through catalytic activation by readily available Ni(OTf)₂ in comparison to systems employing our previously in-house prepared Ni(4-F-PhCN)₄(OTf)₂. We anticipate that the bench-stable and inexpensive Ni(OTf)₂, coupled with little to no extra laboratory training to set up the glycosylation reaction and no requirement of specialized equipment, should make this methodology be readily

SUBMITTER: Sletten ET 

PROVIDER: S-EPMC5113030 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature