Reduced Microvascular Density in Omental Biopsies of Children with Chronic Kidney Disease.

ABSTRACT:

Background

Endothelial dysfunction is an early manifestation of cardiovascular disease (CVD) and consistently observed in patients with chronic kidney disease (CKD). We hypothesized that CKD is associated with systemic damage to the microcirculation, preceding macrovascular pathology. To assess the degree of "uremic microangiopathy", we have measured microvascular density in biopsies of the omentum of children with CKD.

Patients and methods

Omental tissue was collected from 32 healthy children (0-18 years) undergoing elective abdominal surgery and from 23 age-matched cases with stage 5 CKD at the time of catheter insertion for initiation of peritoneal dialysis. Biopsies were analyzed by independent observers using either a manual or an automated imaging system for the assess

SUBMITTER: Burkhardt D 

PROVIDER: S-EPMC5113061 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature