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Lineage mapper: A versatile cell and particle tracker.


ABSTRACT: The ability to accurately track cells and particles from images is critical to many biomedical problems. To address this, we developed Lineage Mapper, an open-source tracker for time-lapse images of biological cells, colonies, and particles. Lineage Mapper tracks objects independently of the segmentation method, detects mitosis in confluence, separates cell clumps mistakenly segmented as a single cell, provides accuracy and scalability even on terabyte-sized datasets, and creates division and/or fusion lineages. Lineage Mapper has been tested and validated on multiple biological and simulated problems. The software is available in ImageJ and Matlab at isg.nist.gov.

SUBMITTER: Chalfoun J 

PROVIDER: S-EPMC5113068 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Lineage mapper: A versatile cell and particle tracker.

Chalfoun Joe J   Majurski Michael M   Dima Alden A   Halter Michael M   Bhadriraju Kiran K   Brady Mary M  

Scientific reports 20161117


The ability to accurately track cells and particles from images is critical to many biomedical problems. To address this, we developed Lineage Mapper, an open-source tracker for time-lapse images of biological cells, colonies, and particles. Lineage Mapper tracks objects independently of the segmentation method, detects mitosis in confluence, separates cell clumps mistakenly segmented as a single cell, provides accuracy and scalability even on terabyte-sized datasets, and creates division and/or  ...[more]

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