The Regulation of Inherently Autoreactive VH4-34-Expressing B Cells in Individuals Living in a Malaria-Endemic Area of West Africa.

ABSTRACT: Plasmodium falciparum malaria is a deadly infectious disease in which Abs play a critical role in naturally acquired immunity. However, the specificity and nature of Abs elicited in response to malaria are only partially understood. Autoreactivity and polyreactivity are common features of Ab responses in several infections and were suggested to contribute to effective pathogen-specific Ab responses. In this article, we report on the regulation of B cells expressing the inherently autoreactive VH4-34 H chain (identified by the 9G4 mAb) and 9G4⁺ plasma IgG in adults and children living in a P. falciparum malaria-endemic area in West Africa. The frequency of 9G4⁺ peripheral blood CD19⁺ B cells was similar in United States adults and African adults and children

SUBMITTER: Hart GT 

PROVIDER: S-EPMC5113821 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature