Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases.

ABSTRACT:

Background

Personalised medicine, including biomarkers for treatment selection, may provide new algorithms for more effective treatment of patients. Genetic variation may impact drug response and genetic markers could help selecting the best treatment strategy for the individual patient.

Aim

To identify polymorphisms and candidate genes from the literature that are associated with anti-tumour necrosis factor (TNF) treatment response in patients with inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis.

Methods

We performed a PubMed literature search and retrieved studies reporting original data on association between polymorphisms and anti-TNF treatment response and conducted a meta-analysis.

Results

A functional polymorphism in FCGR3A

SUBMITTER: Bek S 

PROVIDER: S-EPMC5113857 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature