Drivers of Inter-individual Variation in Dengue Viral Load Dynamics.

ABSTRACT: Dengue is a vector-borne viral disease of humans that endemically circulates in many tropical and subtropical regions worldwide. Infection with dengue can result in a range of disease outcomes. A considerable amount of research has sought to improve our understanding of this variation in disease outcomes and to identify predictors of severe disease. Contributing to this research, patterns of viral load in dengue infected patients have been quantified, with analyses indicating that peak viral load levels, rates of viral load decline, and time to peak viremia are useful predictors of severe disease. Here, we take a complementary approach to understanding patterns of clinical manifestation and inter-individual variation in viral load dynamics. Specifically, we statistically fit mathematical w

SUBMITTER: Ben-Shachar R 

PROVIDER: S-EPMC5113863 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature