Lower Platelet Reactivity Is Associated with Presentation of Unstable Coronary Artery Disease.

ABSTRACT: In patients with acute coronary syndrome, high platelet reactivity (PR) is associated with an increased risk of secondary thrombotic events. However, in patients undergoing elective percutaneous coronary intervention (PCI), no association between high PR and outcome has been demonstrated. At present, the relation of PR and clinical symptoms is unknown. To examine the association of PR with clinical indication for diagnostic angiography (stable or unstable coronary artery disease [CAD]), taking into account the influence of P2Y₁₂ inhibitors. A platelet function score (PFS) was determined in 195 patients by quantifying fibrinogen binding and P-selectin expression with flow cytometry. We evaluated the PFS with clinical presentation of stable or unstable CAD, angiographic severity o

SUBMITTER: Leunissen TC 

PROVIDER: S-EPMC5114132 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature