Nuclear Localization of Suppressor of Cytokine Signaling-1 Regulates Local Immunity in the Lung.

ABSTRACT: Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback inhibitor of cytoplasmic Janus kinase and signal transducer and activator of transcription (STAT) signaling. SOCS1 also contains a nuclear localization sequence (NLS), yet, the in vivo importance of nuclear translocation is unknown. We generated transgenic mice containing mutated Socs1ΔNLS that fails to translocate in the cell nucleus (MGL^tg mice). Whereas mice fully deficient for SOCS1 die within the first 3 weeks due to excessive interferon signaling and multiorgan inflammation, mice expressing only non-nuclear Socs1ΔNLS (Socs1^-/-MGL^tg mice) were rescued from early lethality. Canonical interferon gamma signaling was still functional in Socs1^-/-

SUBMITTER: Zimmer J 

PROVIDER: S-EPMC5114302 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature