Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct αβT Cell Receptor Signatures.

ABSTRACT: αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to be recognized. To provide efficient protective anti-viral immunity, a single TCR ideally needs to cross-react with a multitude of pathogenic epitopes. However, the frequency, extent, and mechanisms of TCR cross-reactivity remain unclear, with conflicting results on anti-viral T cell cross-reactivity observed in humans. Namely, both the presence and lack of T cell cross-reactivity have been reported with HLA-A*02:01-restricted epitopes from the Epstein-Barr and influenza viruses (BMLF-1 and M1₅₈, respectively) or with the hepatitis C and influenza viruses (NS3₁₀₇₃ and NA₂₃₁, respectively). Given the high sequence similarity of these paired viral epitopes (56 an

SUBMITTER: Grant EJ 

PROVIDER: S-EPMC5114392 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature