Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death.

ABSTRACT:

Rationale

Pulmonary aspergillosis is a lethal mold infection in the immunocompromised host. Understanding initial control of infection and how this is altered in the immunocompromised host are key goals for comprehension of the pathogenesis of pulmonary aspergillosis.

Objectives

To characterize the outcome of human macrophage infection with Aspergillus fumigatus and how this is altered in transplant recipients on calcineurin inhibitor immunosuppressants.

Methods

We defined the outcome of human macrophage infection with A. fumigatus, as well as the impact of calcineurin inhibitors, through a combination of single-cell fluorescence imaging, transcriptomics, proteomics, and in vivo studies.

Measurements and main results

Macrophage phagocytosis of A. fumigatus enab

SUBMITTER: Shah A 

PROVIDER: S-EPMC5114448 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature