A Nonparametric Regression Approach to Control for Population Stratification in Rare Variant Association Studies.

ABSTRACT: Recently, there is increasing interest to detect associations between rare variants and complex traits. Rare variant association studies usually need large sample sizes due to the rarity of the variants, and large sample sizes typically require combining information from different geographic locations within and across countries. Although several statistical methods have been developed to control for population stratification in common variant association studies, these methods are not necessarily controlling for population stratification in rare variant association studies. Thus, new statistical methods that can control for population stratification in rare variant association studies are needed. In this article, we propose a principal component based nonparametric regression (PC-nonp) ap

SUBMITTER: Sha Q 

PROVIDER: S-EPMC5114546 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature