Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma.

ABSTRACT: RCC usually develops and progresses asymptomatically and, when detected, it is frequently at advanced stages and metastatic, entailing a dismal prognosis. Therefore, there is an obvious demand for new strategies enabling an earlier diagnosis. The importance of metabolic rearrangements for carcinogenesis unlocked a new approach for cancer research, catalyzing the increased use of metabolomics. The present study aimed the NMR metabolic profiling of RCC in urine samples from a cohort of RCC patients (n = 42) and controls (n = 49). The methodology entailed variable selection of the spectra in tandem with multivariate analysis and validation procedures. The retrieval of a disease signature was preceded by a systematic evaluation of the impacts of subject age, gender, BMI, and smoking habits. Th

SUBMITTER: Monteiro MS 

PROVIDER: S-EPMC5114559 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature