Elevated Mitochondrial DNA Copy Number in Peripheral Blood and Tissue Predict the Opposite Outcome of Cancer: A Meta-Analysis.

ABSTRACT: Previous studies have suggested that mitochondrial DNA (mtDNA) copy number was associated with cancer risk. However, no solid conclusion revealed the potential predictive value of mtDNA copy number for cancer prognosis. The present meta-analysis was performed to clarify the problem. Hence, we performed a systematic search in PubMed, EmBase, Web of Science databases independently and a total of eighteen studies comprising 3961 cases satisfied the criteria and finally enrolled. Our results didn't show the association between them but significant heterogeneity in overall analysis (OS: HR = 0.923, 95% CI: 0.653-1.306, p = 0.652; DFS: HR = 0.997, 95% CI: 0.599-1.659, p = 0.99). However, subgroup analysis stratified by sample came to the opposite conclusion. High level mitochondrial DNA copy num

SUBMITTER: Chen N 

PROVIDER: S-EPMC5114650 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature