Osteogenic and bactericidal surfaces from hydrothermal titania nanowires on titanium substrates.

ABSTRACT: Nanotopographical cues on Ti have been shown to elicit different cell responses such as cell differentiation and selective growth. Bone remodelling is a constant process requiring specific cues for optimal bone growth and implant fixation. Moreover, biofilm formation and the resulting infection on surgical implants is a major issue. Our aim is to identify nanopatterns on Ti surfaces that would be optimal for both bone remodelling and for reducing risk of bacterial infection. Primary human osteoblast/osteoclast co-cultures were seeded onto Ti substrates with TiO₂ nanowires grown under alkaline conditions at 240 °C for different times (2, 2.5 or 3 h). Cell growth and behaviour was assessed by scanning electron microscopy (SEM), immunofluorescence microscopy, histochemistry and qua

SUBMITTER: Tsimbouri PM 

PROVIDER: S-EPMC5114696 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature