Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood.

ABSTRACT:

Background

Children born from filarial infected mothers are comparatively more susceptible to filarial infection than the children born to uninfected mothers. But the mechanism of such increased susceptibility to infection in early childhood is not exactly known. Several studies have shown the association of active filarial infection with T cell hypo-responsiveness which is mediated by regulatory T cells (Tregs). Since the Tregs develop in the thymus from CD4+ CD25hi thymocytes at an early stage of the human fetus, it can be hypothesized that the maternal infection during pregnancy affects the development of Tregs in children at birth as well as early childhood. Hence the present study was designed to test the hypothesis by selecting a cohort of pregnant mothers and children born t

SUBMITTER: Bal M 

PROVIDER: S-EPMC5115651 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature