Levodopa modulates small-world architecture of functional brain networks in Parkinson's disease.

ABSTRACT:

Background

PD is associated with disrupted connectivity to a large number of distributed brain regions. How the disease alters the functional topological organization of the brain, however, remains poorly understood. Furthermore, how levodopa modulates network topology in PD is largely unknown. The objective of this study was to use resting-state functional MRI and graph theory to determine how small-world architecture is altered in PD and affected by levodopa administration.

Methods

Twenty-one PD patients and 20 controls underwent functional MRI scanning. PD patients were scanned off medication and 1 hour after 200 mg levodopa. Imaging data were analyzed using 226 nodes comprising 10 intrinsic brain networks. Correlation matrices were generated for each subject and converte

SUBMITTER: Berman BD 

PROVIDER: S-EPMC5115928 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature