Follicular helper T cells mediate IgE antibody response to airborne allergens.

ABSTRACT:

Background

T_H2 cells have long been believed to play a pivotal role in allergic immune responses, including IgE antibody production and type 2 cytokine-mediated inflammation and pathology. A new T-cell subset, follicular helper T (T_FH) cells, is specialized in supporting B-cell maturation and antibody production.

Objective

We sought to investigate the roles of T_FH cells in allergic immune responses.

Methods

Naive mice were exposed to cytokines or natural allergens through the airways. Development of allergic immune responses was analyzed by collecting draining lymph nodes and sera and by challenging the animals. Cytokine reporter mice and gene-deficient mice were used to dissect the immunologic mechanisms.

Results

We observed th

SUBMITTER: Kobayashi T 

PROVIDER: S-EPMC5115999 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature