Pooled genome wide association detects association upstream of FCRL3 with Graves' disease.

ABSTRACT:

Background

Graves' disease is an autoimmune thyroid disease of complex inheritance. Multiple genetic susceptibility loci are thought to be involved in Graves' disease and it is therefore likely that these can be identified by genome wide association studies. This study aimed to determine if a genome wide association study, using a pooling methodology, could detect genomic loci associated with Graves' disease.

Results

Nineteen of the top ranking single nucleotide polymorphisms including HLA-DQA1 and C6orf10, were clustered within the Major Histo-compatibility Complex region on chromosome 6p21, with rs1613056 reaching genome wide significance (p = 5 × 10^-8). Technical validation of top ranking non-Major Histo-compatablity complex single nucleotide polymorphisms with

SUBMITTER: Khong JJ 

PROVIDER: S-EPMC5116198 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature