Thalidomide promotes transplanted cell engraftment in the rat liver by modulating inflammation and endothelial integrity.

ABSTRACT:

Background & aims

For liver-directed cell therapy, efficient engraftment of transplanted cells is critical. This study delineated whether anti-inflammatory and endothelial disrupting properties of thalidomide could promote transplanted cell engraftment and proliferation in liver.

Methods

We used dipeptidyl peptidase IV-deficient rats for cell transplantation studies, including gene expression analysis, morphological tissue analysis, serological assays, cell culture assays, and assays of transplanted cell engraftment and proliferation.

Results

Thalidomide-pretreatment increased engraftment and proliferation of transplanted hepatocytes due to decreased inflammation. Moreover, thalidomide exacerbated cell transplantation-induced endothelial injury. This combined anti-inf

SUBMITTER: Viswanathan P 

PROVIDER: S-EPMC5116265 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature