Extraocular motoneuron pools develop along a dorsoventral axis in zebrafish, Danio rerio.

ABSTRACT: Both spatial and temporal cues determine the fate of immature neurons. A major challenge at the interface of developmental and systems neuroscience is to relate this spatiotemporal trajectory of maturation to circuit-level functional organization. This study examined the development of two extraocular motor nuclei (nIII and nIV), structures in which a motoneuron's identity, or choice of muscle partner, defines its behavioral role. We used retro-orbital dye fills, in combination with fluorescent markers for motoneuron location and birthdate, to probe spatial and temporal organization of the oculomotor (nIII) and trochlear (nIV) nuclei in the larval zebrafish. We describe a dorsoventral organization of the four nIII motoneuron pools, in which inferior and medial rectus motoneurons occupy dor

SUBMITTER: Greaney MR 

PROVIDER: S-EPMC5116274 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature