Computational Modeling of Venous Sinus Stenosis in Idiopathic Intracranial Hypertension.

ABSTRACT:

Background and purpose

Idiopathic intracranial hypertension has been associated with dural venous sinus stenosis in some patients, but the hemodynamic environment of the dural venous sinuses has not been quantitatively described. Here, we present the first such computational fluid dynamics model by using patient-specific blood pressure measurements.

Materials and methods

Six patients with idiopathic intracranial hypertension and at least 1 stenosis or atresia at the transverse/sigmoid sinus junction underwent MR venography followed by cerebral venography and manometry throughout the dural venous sinuses. Patient-specific computational fluid dynamics models were created by using MR venography anatomy, with venous pressure measurements as boundary conditions. Blood flow and wa

SUBMITTER: Levitt MR 

PROVIDER: S-EPMC5116292 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature