Subcortical volumetric abnormalities in bipolar disorder.

ABSTRACT: Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10^-7) and thalamus (d=-0.148; P=4.27 × 10^-3) and e

SUBMITTER: Hibar DP 

PROVIDER: S-EPMC5116479 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature