Biomolecular Network-Based Synergistic Drug Combination Discovery.

ABSTRACT: Drug combination is a powerful and promising approach for complex disease therapy such as cancer and cardiovascular disease. However, the number of synergistic drug combinations approved by the Food and Drug Administration is very small. To bridge the gap between urgent need and low yield, researchers have constructed various models to identify synergistic drug combinations. Among these models, biomolecular network-based model is outstanding because of its ability to reflect and illustrate the relationships among drugs, disease-related genes, therapeutic targets, and disease-specific signaling pathways as a system. In this review, we analyzed and classified models for synergistic drug combination prediction in recent decade according to their respective algorithms. Besides, we collected us

SUBMITTER: Li X 

PROVIDER: S-EPMC5116515 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature