Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee T
PROVIDER: S-EPMC5116717 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Banerjee Tuhina T Cilenti Lucia L Taylor Michael M Showman Adrienne A Tatulian Suren A SA Teter Ken K
Infection and immunity 20161118 12
Pertussis toxin (PT) moves from the host cell surface to the endoplasmic reticulum (ER) by retrograde vesicular transport. The catalytic PTS1 subunit dissociates from the rest of the toxin in the ER and then shifts to a disordered conformation which may trigger its export to the cytosol through the quality control mechanism of ER-associated degradation (ERAD). Functional roles for toxin instability and ERAD in PTS1 translocation have not been established. We addressed these issues with the use o ...[more]