The Phosphotransfer Protein CD1492 Represses Sporulation Initiation in Clostridium difficile.

ABSTRACT: The formation of spores is critical for the survival of Clostridium difficile outside the host gastrointestinal tract. Persistence of C. difficile spores greatly contributes to the spread of C. difficile infection (CDI), and the resistance of spores to antimicrobials facilitates the relapse of infection. Despite the importance of sporulation to C. difficile pathogenesis, the molecular mechanisms controlling spore formation are not well understood. The initiation of sporulation is known to be regulated through activation of the conserved transcription factor Spo0A. Multiple regulators influence Spo0A activation in other species; however, many of these factors are not conserved in C. difficile and few novel factors have been identified. Here, we investigated the function of a protein, CD1492

SUBMITTER: Childress KO 

PROVIDER: S-EPMC5116721 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature