Insights into the human mesenchymal stromal/stem cell identity through integrative transcriptomic profiling.

ABSTRACT:

Background

Mesenchymal Stromal/Stem Cells (MSCs), isolated under the criteria established by the ISCT, still have a poorly characterized phenotype that is difficult to distinguish from similar cell populations. Although the field of transcriptomics and functional genomics has quickly grown in the last decade, a deep comparative analysis of human MSCs expression profiles in a meaningful cellular context has not been yet performed. There is also a need to find a well-defined MSCs gene-signature because many recent biomedical studies show that key cellular interaction processes (i.e. inmuno-modulation, cellular cross-talk, cellular maintenance, differentiation, epithelial-mesenchymal transition) are dependent on the mesenchymal stem cells within the stromal niche.

Results

In th

SUBMITTER: Roson-Burgo B 

PROVIDER: S-EPMC5117530 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature