ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells.

ABSTRACT:

Background

Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts including thousands of lncRNAs that generally lack protein coding potential. However, only a small percentage of these molecules has been functionally characterised, and discoveries of specific functions demonstrate layers of complexity. A large percentage of lncRNAs is located in the cytoplasm, associated with ribosomes but the function of the majority of these transcripts is unclear. The current study analyses putative mechanisms of action of the lncRNA species member ZFAS1 that was initially discovered by microarray analysis of murine tissues undergoing mammary gland development. As developmental genes are often deregulated in cancer, here we have studied its function in breast can

SUBMITTER: Hansji H 

PROVIDER: S-EPMC5117590 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature