ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins.

ABSTRACT:

Background

Host genetics is one of several factors known to shape human gut microbiome composition, however, the physiological processes underlying the heritability are largely unknown. Inter-individual differences in host factors secreted into the gut lumen may lead to variation in microbiome composition. One such factor is the ABO antigen. This molecule is not only expressed on the surface of red blood cells, but is also secreted from mucosal surfaces in individuals containing an intact FUT2 gene (secretors). Previous studies report differences in microbiome composition across ABO and secretor genotypes. However, due to methodological limitations, the specific bacterial taxa involved remain unknown.

Results

Here, we sought to determine the relationship of the microbiota to

SUBMITTER: Davenport ER 

PROVIDER: S-EPMC5117602 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature