Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction.

ABSTRACT:

Background

Trichoderma reesei is one of the main sources of biomass-hydrolyzing enzymes for the biotechnology industry. There is a need for improving its enzyme production efficiency. The use of metabolic modeling for the simulation and prediction of this organism's metabolism is potentially a valuable tool for improving its capabilities. An accurate metabolic model is needed to perform metabolic modeling analysis.

Results

A whole-genome metabolic model of T. reesei has been reconstructed together with metabolic models of 55 related species using the metabolic model reconstruction algorithm CoReCo. The previously published CoReCo method has been improved to obtain better quality models. The main improvements are the creation of a unified database of reactions a

SUBMITTER: Castillo S 

PROVIDER: S-EPMC5117618 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature