Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.

ABSTRACT:

Background

Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR).

Methods

Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/- coisogenic strains were used. At the age of 4 months, dexamethasone (2.6 μg/ml) was administered in the drinking water for three days. The lipidemic profile (cholesterol and triacylglycerol concentration in 20 lipoprotein fractions, chylomicron, VLDL, LDL and HDL particle sizes) together with 33 cytokines and hormones in serum and

SUBMITTER: Seda O 

PROVIDER: S-EPMC5117636 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature