Associations between XRCC1 Gene Polymorphisms and Coronary Artery Disease: A Meta-Analysis.

ABSTRACT: Genetic variations that influence DNA repair efficiency may contribute to coronary artery disease (CAD) susceptibility. Previous studies have investigated whether there was evidence of an association between polymorphisms at the X-ray repair cross complementing 1 (XRCC1) gene and susceptibility to CAD, but findings have been inconclusive. We identified eligible studies through a comprehensive literature search to determine whether an association exists between XRCC1 gene polymorphisms and CAD susceptibility. Findings were assessed using the odds ratio (OR) and corresponding 95% confidence interval (CI), which were calculated using a fixed- or random-effects model, based on the heterogeneity of the studies. Ten eligible studies were finally included in this meta-analysis. Our pooled analysi

SUBMITTER: Ma WQ 

PROVIDER: S-EPMC5117741 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature