Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium.

ABSTRACT: Osteoarthritis (OA) is a degenerative joint disease affecting cartilage and is the most common form of arthritis worldwide. One third of OA patients have severe synovitis and less than 10% have no evidence of synovitis. Moreover, synovitis is predictive for more severe disease progression. This offers a target for therapy but more research on the pathophysiological processes in the synovial tissue of these patients is needed. Functional studies performed with synovial tissue will be more approachable when this material, that becomes available by joint replacement surgery, can be stored for later use. We set out to determine the consequences of slow-freezing of human OA synovial tissue. Therefore, we validated a method that can be applied in every routine laboratory and performed a comparat

SUBMITTER: Broeren MG 

PROVIDER: S-EPMC5117761 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature