Lrig1 is a positive prognostic marker in hepatocellular carcinoma.

ABSTRACT:

Background

The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide. As a consequence, there is an urgent need for identifying molecular markers of HCC development and progression. Recently, several studies have suggested that the Lrig1 may have prognostic implications in various cancer types, but its clinical value in HCC is not well evaluated.

Materials and methods

In this study, the expression level of Lrig1 was examined in 133 HCC tissues and adjacent normal tissues by immunohistochemistry. Furthermore, potential associations between Lrig1 expression and the carcinoma clinical parameters were investigated, including recurrence and survival rate. We silenced the Lrig1 in the normal liver cell line (LO2) and liver cancer cell line (Hep-G2) in vitro by the s

SUBMITTER: Yang B 

PROVIDER: S-EPMC5117876 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature