A Novel Respiratory Motion Perturbation Model Adaptable to Patient Breathing Irregularities.

ABSTRACT:

Purpose

To develop a physical, adaptive motion perturbation model to predict tumor motion using feedback from dynamic measurement of breathing conditions to compensate for breathing irregularities.

Methods and materials

A novel respiratory motion perturbation (RMP) model was developed to predict tumor motion variations caused by breathing irregularities. This model contained 2 terms: the initial tumor motion trajectory, measured from 4-dimensional computed tomography (4DCT) images, and motion perturbation, calculated from breathing variations in tidal volume (TV) and breathing pattern (BP). The motion perturbation was derived from the patient-specific anatomy, tumor-specific location, and time-dependent breathing variations. Ten patients were studied, and 2 amplitude-binned

SUBMITTER: Yuan A 

PROVIDER: S-EPMC5118064 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature