Copper-64 labeled liposomes for imaging bone marrow.

ABSTRACT:

Introduction

Bone marrow is the soft tissue compartment inside the bones made up of hematopoietic cells, adipocytes, stromal cells, phagocytic cells, stem cells, and sinusoids. While [¹⁸F]-FLT has been utilized to image proliferative marrow, to date, there are no reports of particle based positron emission tomography (PET) imaging agents for imaging bone marrow. We have developed copper-64 labeled liposomal formulation that selectively targets bone marrow and therefore serves as an efficient PET probe for imaging bone marrow.

Methods

Optimized liposomal formulations were prepared with succinyl PE, DSPC, cholesterol, and mPEG-DSPE (69:39:1:10:0.1) with diameters of 90 and 140nm, and were doped with DOTA-Bn-DSPE for stable ⁶⁴Cu incorporation into liposome

SUBMITTER: Lee SG 

PROVIDER: S-EPMC5118102 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature