Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy.

ABSTRACT:

Objective

Diffusion tensor imaging (DTI) has become a popular tool for delineating the location and extent of white matter injury in temporal lobe epilepsy (TLE). However, DTI yields nonspecific measures that are confounded by changes occurring within both the intracellular and extracellular environments. This study investigated whether an advanced diffusion method, restriction spectrum imaging (RSI) could provide a more robust measure of white matter injury in TLE relative to DTI due to RSI's ability to separate intraaxonal diffusion (i.e., neurite density; ND) from diffusion associated with extraaxonal factors (e.g., inflammation; crossing fibers).

Methods

RSI and DTI scans were obtained on 21 patients with TLE and 11 age-matched controls. RSI-derived maps of ND, isotropic

SUBMITTER: Loi RQ 

PROVIDER: S-EPMC5118147 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature